Advances in Cell Culture Process Development: Tools and Techniques for Improving Cell Line Development and Process Optimization
نویسندگان
چکیده
منابع مشابه
Automated dynamic fed-batch process and media optimization for high productivity cell culture process development.
Current industry practices for large-scale mammalian cell cultures typically employ a standard platform fed-batch process with fixed volume bolus feeding. Although widely used, these processes are unable to respond to actual nutrient consumption demands from the culture, which can result in accumulation of by-products and depletion of certain nutrients. This work demonstrates the application of...
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ژورنال
عنوان ژورنال: Biotechnology Progress
سال: 2008
ISSN: 8756-7938
DOI: 10.1021/bp070471q